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While neutrophil elastase is likely to be the major proteinase involved in lung destruction in alpha-1 antitrypsin deficiency, it may not be involved in COPD caused by inhalational exposures

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These processes collectively amplify the apoptotic signaling cascade triggered by endoplasmic reticulum stress, resulting in extensive follicular and stromal cell loss following transplantation

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10.1016/j.soilbio.2021.108307 110

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